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. 2011 Jan-Feb;2(1):28-31.
doi: 10.4161/trns.2.1.13950.

Mediator and post-recruitment regulation of RNA polymerase II

Matthew T Knuesel  1 , Dylan J Taatjes
Affiliations

Mediator and post-recruitment regulation of RNA polymerase II

Matthew T Knuesel et al. Transcription. 2011 Jan-Feb.

Abstract

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

Keywords: CDK8; DSIF; Myc; NELF; P-TEFb; p53; review.

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Figures

Figure 1
Figure 1
p53 binds a surface within MED17 that is not targeted by other transcription factors.
See this image and copyright information in PMC

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