Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar-Apr;1(2):116-31.
doi: 10.4161/bbug.1.2.10484. Epub 2009 Nov 2.

Recombinant organisms for production of industrial products

Jose-Luis Adrio  1 , Arnold L Demain
Affiliations
Review

Recombinant organisms for production of industrial products

Jose-Luis Adrio et al. Bioeng Bugs. 2010 Mar-Apr.

Abstract

A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products.

Keywords: antibiotics; antitumor agents; biopharmaceuticals; cholesterol-lowering agents; enzymes; genetic recombination; industrial products; primary metabolites; secondary metabolites.

PubMed Disclaimer

References

    1. Jarai M. Genetic recombination in Streptomyces aureofaciens. Acta Microbiol Acad Sci Hungary. 1961;8:73–79. - PubMed
    1. Mindlin SZ. Genetic recombination in the actinomycete breeding. In: Sermonti G, Alacevic M, editors. Genetics and Breeding of Streptomyces. Zagreb: Yugoslav Academy of Sciences and Arts; 1969. pp. 147–159.
    1. Kieser HM, Kieser T, Hopwood DA. A combined genetic and physical map of the Streptomyces coelicolor A3(2) chromosome. J Bacteriol. 1992;174:5496–5507. - PMC - PubMed
    1. Ryu DDY, Kim KS, Cho NY, Pai HS. Genetic recombination in Micromonospora rosaria by protoplast fusion. Appl Environ Microbiol. 1983;45:1854–1858. - PMC - PubMed
    1. Yoneda Y. Increased production of extracellular enzymes by the synergistic effect of genes introduced into Bacillus subtilis by stepwise transformation. Appl Environ Microbiol. 1980;39:274–276. - PMC - PubMed

Substances

LinkOut - more resources