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Comment
. 2011 Feb 18;331(6019):863-4.
doi: 10.1126/science.1202372.

Cell biology. A hand to support the implantation window

Sylvia C Hewitt  1 , Kenneth S Korach
Affiliations
Comment

Cell biology. A hand to support the implantation window

Sylvia C Hewitt et al. Science. .

Abstract

A signaling pathway connects ovarian hormones to preparation of the mammalian uterus for pregnancy.

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Figures

Figure
Figure. Implantation signals
Stromal cells respond to progesterone during pregnancy by activating the transcription factor Hand2. This triggers a signaling cascade that blocks estrogen receptor (ERα) signaling in uterine epithelial cells, thereby creating an epithelium that is receptive for embryo implantation.
See this image and copyright information in PMC

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