Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan;18(1):e9-e18.
doi: 10.3747/co.v18i1.623.

Immune therapy for breast cancer in 2010-hype or hope?

A Florescu  1 , E Amir, N Bouganim, M Clemons
Affiliations

Immune therapy for breast cancer in 2010-hype or hope?

A Florescu et al. Curr Oncol. 2011 Jan.

Abstract

The identification of numerous breast cancer antigens has generated increasing enthusiasm for the application of immune-based therapies in breast malignancies. Although the use of monoclonal antibodies has revolutionized the "targeted therapy" of breast cancer, and the immunomodulatory effects of bisphosphonates continue to be evaluated, few studies to date have demonstrated widespread utility for other forms of immunotherapy. The present review assesses modern research and explores whether the hopes for immunotherapy can overcome the hype.

Keywords: Breast cancer; cancer vaccine; cytokine; immunotherapy; monoclonal antibody.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Yang JC, Childs R. Immunotherapy for renal cell carcinoma. J Clin Oncol. 2006;24:5576–83. doi: 10.1200/JCO.2006.08.3774. - DOI - PubMed
    1. Stewart TH. Evidence for immune facilitation of breast cancer growth and for the immune promotion of oncogenesis in breast cancer. Medicina (B Aires) 1996;56(suppl 1):13–24. - PubMed
    1. Ding L, Lalani EN, Reddish M, et al. Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human muc1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human muc1 gene. Cancer Immunol Immunother. 1993;36:9–17. doi: 10.1007/BF01789125. - DOI - PMC - PubMed
    1. Acres RB, Hareuveni M, Balloul JM, Kieny MP. Vaccinia virus muc1 immunization of mice: immune response and protection against the growth of murine tumors bearing the muc1 antigen. J Immunother Emphasis Tumor Immunol. 1993;14:136–43. - PubMed
    1. Apostolopoulos V, Xing PX, McKenzie IF. Murine immune response to cells transfected with human muc1: immunization with cellular and synthetic antigens. Cancer Res. 1994;54:5186–93. - PubMed

LinkOut - more resources