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Case Reports
. 2011 Oct;39(5):417-9.
doi: 10.1007/s00240-011-0364-z. Epub 2011 Feb 18.

Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome

Mi Mi Oh  1 , Byeong Kuk Ham, Seok Ho Kang, Jae Hyun Bae, Je Jong Kim, Ki Hwan Yoo, Duck Ki Yoon, Du Geon Moon
Affiliations
Case Reports

Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome

Mi Mi Oh et al. Urol Res. 2011 Oct.

Abstract

Lesch-Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. We report a case of renal pelvis calculi which was dissolved within 10 days of urine alkalinization and hydration.

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