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. 2011 Apr;15 Suppl 1(Suppl 1):S66-71.
doi: 10.1007/s10461-011-9899-9.

Rectal microbicides: can we make them and will people use them?

Ian McGowan  1
Affiliations

Rectal microbicides: can we make them and will people use them?

Ian McGowan. AIDS Behav. 2011 Apr.

Abstract

The results of the CAPRISA 004 and iPrEx HIV prevention studies have demonstrated that topical or systemic use of antiretroviral agents can significantly reduce the risk of HIV acquisition associated with unprotected vaginal or anal sexual intercourse. However, the effect size in these studies was relatively modest and product adherence was generally poor. These observations suggest the need for new approaches to HIV prevention, especially for high risk MSM. Rates of lubricant use are high in MSM practicing receptive anal sex. Consequently, the development of an antiretroviral rectal microbicide gel may provide a safe and effective means of preventing HIV infection with an intervention that is likely to have high acceptability among the target population. The purpose of this article is to describe the challenges and progress in the development of rectal microbicides for HIV prevention.

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Figures

Fig. 1
Fig. 1
Microbicide acceptability and safety in young men [McGowan and Carballo-Dieguez (R01: HD059533-01A1)]: study stages and eligibility criteria
See this image and copyright information in PMC

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