Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;12(2):267-75.
doi: 10.2217/pgs.10.186.

Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy

Barry S Rosenstein  1
Affiliations

Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy

Barry S Rosenstein. Pharmacogenomics. 2011 Feb.

Abstract

Although cancer treatment with radiation can produce high cure rates, adverse effects often result from radiotherapy. These toxicities are manifested as damage to normal tissues and organs in the radiation field. In recognition of the substantial variation in the intrinsic response of individuals to radiation, an effort began approximately 10 years ago to discover the genetic markers, primarily SNPs, which are associated with susceptibility for the development of these adverse responses to radiation therapy. The goal of this research is to identify the SNPs that could serve as the basis of an assay to predict which cancer patients are most likely to develop complications resulting from radiotherapy. This would permit personalization and optimization of the treatment plan for each cancer patient.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bentzen SM, Constine LS, Deasy JO. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010;76(Suppl 3):S3–S9. - PMC - PubMed
    1. Safwat A, Bentzen SM, Turesson I, Hendry JH. Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy. Int J Radiat Oncol Biol Phys. 2002;52(1):198–204. Study that provides evidence of inherent differences in radiosensitivity between individuals as well as evidence that genetic factors may play a role in accounting for this heterogenity in radiation response. - PubMed
    1. Begg AC, Russell NS, Knaken H, Lebesque JV. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int J Radiat Biol. 1993;64(4):393–405. - PubMed
    1. Ozsahin M, Crompton NE, Gourgou S, et al. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a prospective study in 399 patients. Clin Cancer Res. 2005;11(20):7426–7433. - PubMed
    1. Rodningen OK, Borresen-Dale AL, Alsner J, et al. Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis. Radiother Oncol. 2008;86(3):314–320. - PubMed

Publication types