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Comment
. 2011 Feb 18;144(4):465-6.
doi: 10.1016/j.cell.2011.01.037.

Targeting aneuploidy for cancer therapy

Eusebio Manchado  1 , Marcos Malumbres
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Free article
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Targeting aneuploidy for cancer therapy

Eusebio Manchado et al. Cell. .
Free article

Abstract

Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?

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