Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May 1;203(9):1292-300.
doi: 10.1093/infdis/jir014. Epub 2011 Feb 18.

Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status

Huynh T L Duyen  1 , Tran V Ngoc, Do T Ha, Vu T T Hang, Nguyen T T Kieu, Paul R Young, Jeremy J Farrar, Cameron P Simmons, Marcel Wolbers, Bridget A Wills
Affiliations

Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status

Huynh T L Duyen et al. J Infect Dis. .

Abstract

We describe the magnitude and kinetics of plasma viremia and nonstructural protein 1 (sNS1) levels in sequential samples from 167 children with acute dengue, enrolled early in a community study in Vietnam. All children recovered fully, and only 5 required hospitalization. Among those with dengue virus type 1 (DENV-1), plasma viremia was significantly greater in primary (49) than secondary (44) infections and took longer to resolve. In primary DENV-2 and 3 infections, viremia was significantly lower than among primary DENV-1 infections. Concentrations of sNS1 were significantly higher for DENV-1 than for DENV-2 after adjusting for viremia, with marked differences in the kinetic profiles between primary and secondary infections. Secondary infection and higher viremia were independent predictors of more severe thrombocytopenia, and higher viremia was associated with a small increase in hemoconcentration. Our findings identify clear serotype and immune-status related effects on the dynamics of dengue viremia and sNS1 responses, together with associations with important clinical parameters.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Dengue viremia kinetics in 167 children with dengue, by serotype and immune status, presented according to illness day. Gray lines correspond to individual children, and the thick lines correspond to loess scatter plot smoothers.
Figure 2.
Figure 2.
Plasma sNS1 concentration kinetics in 82 children with dengue, by serotype and immune status, presented according to illness day. Gray lines correspond to individual children, and the thick lines correspond to loess scatter plot smoothers. (Only one child with secondary DENV-3 was assessed.)
Figure 3.
Figure 3.
Boxplots of serial platelet counts in 167 children with dengue during illness days 3–8, by serotype. Gray boxplots correspond to children with primary infection, and white boxplots correspond to children with secondary infection. (Platelet values >350,000 cells/μL were truncated at that value in the display.)
See this image and copyright information in PMC

References

    1. WHO. Dengue: Guidelines for diagnosis, treatment, prevention and control. Geneva: World Health Organization; 2009. - PubMed
    1. Pediatric Dengue Vaccine Initiative, 2009. Global burden of dengue. http://www.pdvi.org/about_dengue/GBD.asp. Accessed 20 July 2010.
    1. Green S, Rothman A. Immunopathological mechanisms in dengue and dengue hemorrhagic fever. Curr Opin Infect Dis. 2006;19:429–36. - PubMed
    1. Kliks S, Nimmanitya S, Nisalak A, Burke D. Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg. 1988;38:411–9. - PubMed
    1. Chau TN, Anders KL, Lien le B, et al. Clinical and virological features of Dengue in Vietnamese infants. PLoS Negl Trop Dis. 2010;4:e657. - PMC - PubMed

Publication types

Substances