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Comment
. 2011 May;13(3):353-4.
doi: 10.1038/aja.2011.7. Epub 2011 Feb 21.

Bmi-1, stem cells and prostate carcinogenesis

David Moscatelli  1 , E Lynette Wilson
Affiliations
Comment

Bmi-1, stem cells and prostate carcinogenesis

David Moscatelli et al. Asian J Androl. 2011 May.
No abstract available

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Figures

Figure 1
Figure 1
Signaling pathways in prostate tumor-initiating cells may be perturbed counterparts of those expressed in normal prostate stem cells. The pathways involved in self-renewal of normal stem cells are tightly regulated (formula image). The balance between proliferation and differentiation is maintained by tumor suppressor molecules and molecules that cause self renewal. A decrease of suppressor molecules and/or an increase in molecules that promote self-renewal can result in tumor initiation and tumor progression.
See this image and copyright information in PMC

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References

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