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Comment
. 2011 Mar;13(3):195-7.
doi: 10.1038/ncb2177. Epub 2011 Feb 20.

p53 guards the metabolic pathway less travelled

Eyal Gottlieb
Comment

p53 guards the metabolic pathway less travelled

Eyal Gottlieb. Nat Cell Biol. 2011 Mar.

Abstract

Glucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer cells. The tumour suppressor p53 has now been reported to block a metabolic pathway (the pentose phosphate pathway) that diverts glucose away from bioenergetic into biosynthetic routes.

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References

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