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Randomized Controlled Trial
. 2011 Dec;18(4):333-41.
doi: 10.1007/s12529-010-9079-8.

Effects of a weight loss intervention on body mass, fitness, and inflammatory biomarkers in overweight or obese breast cancer survivors

Bilgé Pakiz  1 , Shirley W Flatt, Wayne A Bardwell, Cheryl L Rock, Paul J Mills
Affiliations
Randomized Controlled Trial

Effects of a weight loss intervention on body mass, fitness, and inflammatory biomarkers in overweight or obese breast cancer survivors

Bilgé Pakiz et al. Int J Behav Med. 2011 Dec.

Abstract

Background: Obesity is characterized by chronic mild inflammation and may influence the risk and progression of cancer.

Purpose: The current study is an exploratory analysis of the effect of a weight loss intervention that emphasized increased physical activity on inflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6], interleukin-8 [IL-8], and vascular endothelial growth factor [VEGF]) at the end of the 16-week intervention period in overweight breast cancer survivors.

Methods: Study participants averaged 56 years of age (N=68). Intervention participants (n=44 vs. 24 controls) participated in a cognitive behavioral therapy-based weight management program as part of an exploratory randomized trial. The intervention incorporated strategies to promote increased physical activity and diet modification. Baseline and 16-week data included height, weight, body composition, physical activity level, and biomarkers IL-6, IL-8, TNF-α, and VEGF.

Results: Weight loss was significantly greater in the intervention group than controls (-5.7 [3.5] vs. 0.2 [4.1] kg, P<0.001). Paired t tests noted favorable changes in physical activity level (P<0.001 intervention, P=0.70 control), marginally lower IL-6 levels (P=0.06 intervention, P=0.25 control) at 16 weeks for participants in the intervention group, and lower TNF-α levels for participants in the intervention (P<0.05) and control groups (P<0.001). Increased physical activity was associated with favorable changes in IL-6 for participants in the intervention group (R(2) =0.18; P<0.03).

Conclusion: Favorable changes in cytokine levels were observed in association with weight loss in this exploratory study with overweight breast cancer survivors.

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Figures

Fig. 1
Fig. 1
CONSORT Chart for Healthy Weight Management Study including recruitment information
Fig. 2
Fig. 2
Weight loss intervention curriculum topics
See this image and copyright information in PMC

References

    1. American Cancer Society Cancer statistics presentation. American Cancer Society, Inc. 2008;2008:1–47.
    1. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, et al. Cancer statistics, 2004. CA Cancer J Clin. 2004;54:8–29. doi: 10.3322/canjclin.54.1.8. - DOI - PubMed
    1. Bines J, Gradishar WJ. Primary care issues for the breast cancer survivor. Compr Ther. 1997;23:605–11. - PubMed
    1. Brown BW, Brauner C, Minnotte MC. Noncancer deaths in white adult cancer patients. J Natl Cancer Inst. 1993;85:979–87. doi: 10.1093/jnci/85.12.979. - DOI - PubMed
    1. Cleary MP, Maihle NJ. The role of body mass index in the relative risk of developing premenopausal versus postmenopausal breast cancer. Proc Soc Exp Biol Med. 1997;216:28–43. - PubMed

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