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. 2012 Feb;28(2):243-50.
doi: 10.1007/s10554-011-9831-4. Epub 2011 Feb 20.

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

Serina A Neumann  1 , Katherine J Linder, Matthew F Muldoon, Kimberly Sutton-Tyrrell, Christopher Kline, Catherine J Shrader, Elizabeth C Lawrence, Robert E Ferrell, Stephen B Manuck
Affiliations

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

Serina A Neumann et al. Int J Cardiovasc Imaging. 2012 Feb.

Abstract

Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30-55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk.

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