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. 2012 Feb;28(2):243-50.
doi: 10.1007/s10554-011-9831-4. Epub 2011 Feb 20.

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

Serina A Neumann  1 , Katherine J Linder, Matthew F Muldoon, Kimberly Sutton-Tyrrell, Christopher Kline, Catherine J Shrader, Elizabeth C Lawrence, Robert E Ferrell, Stephen B Manuck
Affiliations

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

Serina A Neumann et al. Int J Cardiovasc Imaging. 2012 Feb.

Abstract

Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30-55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk.

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References

    1. O'Donnell CJ, Cupples LA, D'Agostino RB, Fox CS, Hoffmann U, Hwang SJ, et al. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet. 2007;8(Suppl 1):S4. - PMC - PubMed
    1. Roy H, Bhardwaj S, Yla-Herttuala S. Molecular genetics of atherosclerosis. Hum Genet. 2009 Mar 20;125:467–491. - PubMed
    1. Kleiger RE, Bigger JT, Moss AJ. Decreased heart rate variability and its association with increased mortality after myocardial infraction. Am J Cardiol. 1997;73:845–849. - PubMed
    1. Tsuji H, Larson MG, Venditti FJ, Manders ES, Evans JC, Feldman CL, et al. Impact of reduced heart rate variability on risk for cardiac events—the Framingham Heart Study. Circulation. 1996;94(11):2850–2855. - PubMed
    1. Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med. 2005;67:S29–S33. - PubMed

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