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. 2011 Mar 18;13(6):1362-5.
doi: 10.1021/ol200054w. Epub 2011 Feb 21.

A highly selective pyrophosphate sensor based on ESIPT turn-on in water

Wei-Hua Chen  1 , Yu Xing, Yi Pang
Affiliations

A highly selective pyrophosphate sensor based on ESIPT turn-on in water

Wei-Hua Chen et al. Org Lett. .

Abstract

Pyrophosphate (PPi) is a biologically important target. A binuclear system 3•2Zn is found to selectively recognize PPi, leading to a ratiometric fluorescent sensor at pH 7.4 in water. The binding event triggered a large fluorescence response (∼100 nm bathochromic shift) by turning on the excited state intramolecular proton transfer (ESIPT). Detection of PPi released from a PCR experiment indicated that this new probe could be a useful tool in bioanalytical applications.

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