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Review
. 2011 Feb;98(2):E19-24.
doi: 10.1684/bdc.2010.1295.

Cytotoxic T cells - stroma interactions

Muhammad Zaeem Noman  1 , Houssem Benlalam, Meriem Hasmim, Salem Chouaib
Affiliations
Review

Cytotoxic T cells - stroma interactions

Muhammad Zaeem Noman et al. Bull Cancer. 2011 Feb.

Abstract

The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

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