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. 2011 Jan 27:7:41-7.
doi: 10.2147/VHRM.S15384.

Relevance of tumor angiogenesis patterns as a diagnostic value and prognostic indicator in oral precancer and cancer

Devi Charan Shetty  1 , Puneet Ahuja, D K Taneja, Ajit Singh Rathore, Shivjot Chhina, Upasana Sethi Ahuja, Kiran Kumar, Anshuman Ahuja, Priyanka Rastogi
Affiliations

Relevance of tumor angiogenesis patterns as a diagnostic value and prognostic indicator in oral precancer and cancer

Devi Charan Shetty et al. Vasc Health Risk Manag. .

Abstract

Tumor angiogenesis occurs by recruitment of endothelial cell precursors or by sprouting of existing capillaries, which differ from the normal vasculature by having an altered morphology that can be exploited for diagnosis and as a prognostic indicator. Improved technologies have propelled diagnosis into a new era. These technologies have to be used with great precision. The diagnosis of a dysplastic premalignant lesion of the oral mucosa cannot be based solely on clinical findings. Therefore histologic evaluation of a representative biopsy specimen is necessary. Accurate judgment of the proper site for biopsy is essential for reaching a correct diagnosis. The aim of this report is to analyze the vascular patterns with the help of direct oral microscopy and the technique of stereo-optical microscopy in the oral cavity to select biopsy sites, and compare the outcome of a directed biopsy with that of biopsy specimens obtained from sites selected solely on the basis of clinical criteria. The study sample comprised 50 oral mucosal lesions. A statistically significant difference was noted between samples judged to be microscopically representative sites. We conclude that this method would aid in early and better diagnosis and treatment planning of oral premalignant and malignant lesions by assessing the various vascular patterns in the mucosa.

Keywords: angiogenesis; biopsy site selection; colposcopy; stereomicroscope.

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Figures

Figure 1
Figure 1
A) Network capillaries; B) hairpin capillaries; C) punctation capillaries; D) mosaic capillaries; E, F) atypical capillaries.
Figure 2
Figure 2
A) Photomicrograph depicting network capillary pattern (stereomicroscope, autozoom ×40). B) Photomicrograph depicting network capillary pattern (stereomicroscope using green filter, autozoom ×40).
Figure 3
Figure 3
Photomicrograph depicting punctuate capillary pattern (stereomicroscope using green filter, autozoom ×40).
Figure 4
Figure 4
Photomicrograph depicting mosaic capillary pattern (stereomicroscope using green filter, autozoom ×40).
Figure 5
Figure 5
Photomicrograph depicting atypical capillary pattern (stereomicroscope using green filter, autozoom ×40).
Figure 6
Figure 6
Photomicrograph depicting mild dysplasia in a lesion. Specimen taken after direct clinical examination (H&E, magnification ×10).
Figure 7
Figure 7
Photomicrograph depicting moderate dysplasia in a lesion. Specimen taken after stereo-optical examination (H&E, magnification ×10).
Figure 8
Figure 8
Photomicrograph depicting severe dysplasia in a lesion. Specimen taken after stereo-optical examination (H&E, magnification ×40).
Figure 9
Figure 9
Photomicrograph depicting carcinoma in situ in a lesion. Specimen taken after stereo-optical examination (H&E, magnification ×10).
See this image and copyright information in PMC

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