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Review
. 2010 Nov 24;8(12):2849-70.
doi: 10.3390/md8122849.

Cytotoxic terpene quinones from marine sponges

Marina Gordaliza  1
Affiliations
Review

Cytotoxic terpene quinones from marine sponges

Marina Gordaliza. Mar Drugs. .

Abstract

The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.

Keywords: avarol; avarone; cytotoxicity; terpene hydroquinone; terpene quinone.

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Figures

Figure 1
Figure 1
Nakijiquinones.
Figure 2
Figure 2
Polyfibrospongols, ilimaquinones, smenospongines and related compounds.
Figure 3
Figure 3
Avarols and avarones.
Figure 4
Figure 4
Wiedendiols, corallidictyals, chromazonarols and puupehenols.
Figure 5
Figure 5
Mamanuthaquinone, smecualone, stronglylin and adociasulfates.
Figure 6
Figure 6
Bolinaquinones, renierins, paniceins, popolohuanones and other compounds.
See this image and copyright information in PMC

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