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Review
. 2010 Nov 29;8(12):2871-92.
doi: 10.3390/md8122871.

Potential anti-HIV agents from marine resources: an overview

Thanh-Sang Vo  1 , Se-Kwon Kim
Affiliations
Review

Potential anti-HIV agents from marine resources: an overview

Thanh-Sang Vo et al. Mar Drugs. .

Abstract

Human immunodeficiency virus (HIV) infection causes acquired immune deficiency syndrome (AIDS) and is a global public health issue. Anti-HIV therapy involving chemical drugs has improved the life quality of HIV/AIDS patients. However, emergence of HIV drug resistance, side effects and the necessity for long-term anti-HIV treatment are the main reasons for failure of anti-HIV therapy. Therefore, it is essential to isolate novel anti-HIV therapeutics from natural resources. Recently, a great deal of interest has been expressed regarding marine-derived anti-HIV agents such as phlorotannins, sulfated chitooligosaccharides, sulfated polysaccharides, lectins and bioactive peptides. This contribution presents an overview of anti-HIV therapeutics derived from marine resources and their potential application in HIV therapy.

Keywords: AIDS; anti-HIV agents; marine resources; phlorotannins.

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Figures

Figure 1
Figure 1
Chemical structure of phlorotannins.
Figure 2
Figure 2
Chemical structure of sulfated chitin, chitosan and chitooligosaccharide.
See this image and copyright information in PMC

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