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. 2010 Dec 6;8(12):2936-45.
doi: 10.3390/md8122936.

Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp

Yung-Husan Chen  1 , Chia-Ying Tai, Tsong-Long Hwang, Ching-Feng Weng, Jan-Jung Li, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu, Ping-Jyun Sung
Affiliations

Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp

Yung-Husan Chen et al. Mar Drugs. .

Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

Keywords: cladielloide; cytotoxicity; elastase; eunicellin; octocoral; superoxide anion.

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Figures

Figure 1
Figure 1
The key 1H NMR chemical shift differences Δδ (δS–δR) in ppm for the MTPA esters of 1.
Scheme 1
Scheme 1
The structures of cladielloides A (1) and B (2).
See this image and copyright information in PMC

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