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. 2010 Dec 22;8(12):2976-87.
doi: 10.3390/md8122976.

Biological activity of volatiles from marine and terrestrial bacteria

Stefan Schulz  1 , Jeroen S Dickschat, Brigitte Kunze, Irene Wagner-Dobler, Randi Diestel, Florenz Sasse
Affiliations

Biological activity of volatiles from marine and terrestrial bacteria

Stefan Schulz et al. Mar Drugs. .

Abstract

The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.

Keywords: agar diffusion assay; aromatic compounds; bacterial communication; ketones; lactones; pyrazines; quorum-sensing; sulfur compounds; terpenes.

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Figures

Figure 1
Figure 1
Compounds used in this study. Acids, alcohols, lactones, ketones, amides, pyrazines, sulfur compounds, aromatic compounds, and substances commonly occurring as bacterial volatiles (45–52).
Figure 1
Figure 1
Compounds used in this study. Acids, alcohols, lactones, ketones, amides, pyrazines, sulfur compounds, aromatic compounds, and substances commonly occurring as bacterial volatiles (45–52).
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