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. 2011 Mar 16;133(10):3264-7.
doi: 10.1021/ja1102037. Epub 2011 Feb 22.

Dehydrogenative [4 + 2] cycloaddition of formamides with alkynes through double C-H activation

Yoshiaki Nakao  1 , Eiji Morita, Hiroaki Idei, Tamejiro Hiyama
Affiliations

Dehydrogenative [4 + 2] cycloaddition of formamides with alkynes through double C-H activation

Yoshiaki Nakao et al. J Am Chem Soc. .

Abstract

Formamides having 1-arylalkyl groups on nitrogen undergo an unprecedented dehydrogenative [4 + 2] cycloaddition reaction with alkynes via nickel/AlMe(3) cooperative catalysis to give highly substituted dihydropyridone derivatives in good yields. Notably, the transformation proceeds through double functionalization of C(sp(2))-H and C(sp(3))-H bonds in the formamides.

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