The STEP study provides a hint that vaccine induction of the right CD8+ T cell responses can facilitate immune control of HIV

Editorial

Marcus Altfeld et al. J Infect Dis. 2011.

. 2011 Mar 15;203(6):753-5.

doi: 10.1093/infdis/jiq119.

No abstract available

Comment on

An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the Step study).
Fitzgerald DW, Janes H, Robertson M, Coombs R, Frank I, Gilbert P, Loufty M, Mehrotra D, Duerr A; Step Study Protocol Team. Fitzgerald DW, et al. J Infect Dis. 2011 Mar 15;203(6):765-72. doi: 10.1093/infdis/jiq114. J Infect Dis. 2011. PMID: 21343146 Free PMC article. Clinical Trial.

1. McElrath MJ, De Rosa SC, Moodie Z, et al. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet. 2008;372:1894–05. - PMC - PubMed
1. Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372:1881–93. - PMC - PubMed
1. Corey L, McElrath MJ, Kublin JG. Post-step modifications for research on HIV vaccines. AIDS. 2009;23:3–8. - PMC - PubMed
1. Robb ML. Failure of the Merck HIV vaccine: an uncertain step forward. Lancet. 2008;372:1857–8. - PubMed
1. Uberla K. HIV vaccine development in the aftermath of the STEP study: re-focus on occult HIV infection? PLoS Pathog. 2008;4:e1000114. - PMC - PubMed