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. 2011 May;55(5):2420-3.
doi: 10.1128/AAC.01452-10. Epub 2011 Feb 22.

Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France

Gaelle Cuzon  1 , Jocelyne Ouanich, Remy Gondret, Thierry Naas, Patrice Nordmann
Affiliations

Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France

Gaelle Cuzon et al. Antimicrob Agents Chemother. 2011 May.

Abstract

Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the blaOXA-48 gene and coproduced CTX-M-15 and TEM-1 β-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.

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Figures

Fig. 1.
Fig. 1.
Schematic representation of Tn1999.2, identified with the blaOXA-48 gene in the epidemic clone. Genes and their transcription orientations are represented as horizontal arrows. Black triangles represent inverted repeats of insertion sequence IS1999, and gray triangles represent inverted repeats of insertion sequence IS1R. Target site duplications are indicated below the sequence. Δ indicates that the gene/element is interrupted by an insertion element.
See this image and copyright information in PMC

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