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Randomized Controlled Trial
. 2011 Mar;117(3):636-641.
doi: 10.1097/AOG.0b013e31820ad45b.

Pain experienced using two different methods of endometrial biopsy: a randomized controlled trial

Catherine M Leclair  1 , Joy K Zia, Carmen M Doom, Terry K Morgan, Alison B Edelman
Affiliations
Randomized Controlled Trial

Pain experienced using two different methods of endometrial biopsy: a randomized controlled trial

Catherine M Leclair et al. Obstet Gynecol. 2011 Mar.

Abstract

Objective: To compare patient-reported pain, provider- reported ease of use, and tissue sampling adequacy between endometrial biopsy instruments.

Methods: Women presenting for endometrial biopsy were randomized to either Pipelle or Explora curette. The primary outcome was patient-reported pain with biopsy as measured by a 100-mm visual analog scale. Secondary outcomes included the adequacy of biopsy sample and provider-reported ease of instrument use.

Results: Groups were similar in respect to age, parity, ethnicity, level of dysmenorrhea, menopausal status, and biopsy indication. The most common indication for biopsy was abnormal uterine bleeding. Subject reported pain with biopsy was similar between groups (Pipelle, 6.21 ± 2.41 cm; Explora, 6.91 ± 2.88 cm; P=.14), as was provider-reported ease of use. Although procedure length was significantly shorter for patients in the Pipelle group (4.05 ± 1.48 minutes compared with 5.27 ± 2.53 minutes; P=.007), 38% of Pipelle procedures required two or more passes to obtain a sample compared with only 9% using the Explora (P=.004). The Explora group had a higher proportion of adequate samples (97% compared with 91%; P=.33).

Conclusion: Women's pain during endometrial biopsy does not differ by type of biopsy instrument used.

Clinical trial registration: ClinicalTrials.gov, www.clinicaltrials.gov NCT00613925.

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References

    1. Clark TJ, Barton PM, Coomarasamy A, Gupta JK, Khan KS. Investigating postmenopausal bleeding for endometrial cancer: cost-effectiveness of initial diagnostic strategies. BJOG 2006;113:502–10.
    1. Clark TJ, Mann CH, Shah N, Khan KS, Song F, Gupta JK. Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review. BJOG 2002;109:313–21.
    1. Mishell DR Jr, Kaunitz AM. Devices for endometrial sampling. A comparison. J Reprod Med 1998;43:180–4.
    1. Agostini A, Shojaï R, Cravello L, Rojat-Habib MC, Roger V, Bretelle F, et al. Endometrial biopsy during outpatient hysteroscopy: evaluation and comparison of two devices. Eur J Obstet Gynecol Reprod Biol 2001;97:220–2.
    1. Antoni J, Folch E, Costa J, Foradada CM, Cayuela E, Combalia N, et al. Comparison of cytospat and pipelle endometrial biopsy instruments. Eur J Obstet Gynecol Reprod Biol 1997;72:57–61.

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