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. 1978 Oct;31(10):933-5.
doi: 10.1136/jcp.31.10.933.

Incomplete anaerobiosis as a cause of metronidazole 'resistance'

S E Milne, E J Stokes, P M Waterworth

Incomplete anaerobiosis as a cause of metronidazole 'resistance'

S E Milne et al. J Clin Pathol. 1978 Oct.

Abstract

Clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. Minimum inhibitory concentrations for six strains of Cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. Zones of inhibition with both Cl. welchii and Bacteroides fragilis varied with the amount of air admitted to anaerobic jars.

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References

    1. J Clin Pathol. 1977 Nov;30(11):1028-9 - PubMed

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