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• Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility.

  Scully SS, Tang AJ, Lundh M, Mosher CM, Perkins KM, Wagner BK. Scully SS, et al. J Med Chem. 2013 May 23;56(10):4125-9. doi: 10.1021/jm400397x. Epub 2013 May 13. J Med Chem. 2013. PMID: 23617753 Free PMC article.
• Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.

  Bhattarai P, Hegde P, Li W, Prathipati PK, Stevens CM, Yang L, Zhou H, Pandya A, Cunningham K, Grissom J, Roman Sotelo M, Sowards M, Calisto L, Destache CJ, Rocha-Sanchez S, Gumbart JC, Zgurskaya HI, Jackson M, North EJ. Bhattarai P, et al. J Med Chem. 2023 Jan 12;66(1):170-187. doi: 10.1021/acs.jmedchem.2c00352. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36563291 Free PMC article.
• Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

  Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, Buist N, Terebetski J, Kelly T, Bugianesi R, Priest BT, Dingley KH, Li X, Mitelman S, Salituro G, Trujillo ME, Pachanski M, Kirkland M, Powles MA, Eiermann GJ, Feng Y, Shang J, Howard AD, Ujjainwalla F, Sinz CJ, Debenham JS, Edmondson SD, Nargund RP, Hagmann WK, Li D. Guo L, et al. ACS Med Chem Lett. 2016 Oct 12;7(12):1107-1111. doi: 10.1021/acsmedchemlett.6b00314. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994747 Free PMC article.
• Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease.

  Kim BY, Oh C, Jeon D, Jun I, Lee HK, Kim BR, Park J, Seo KY, Kim KA, Lim D, Lee S, Lee J, Yoon H, Kim TI, Namkung W. Kim BY, et al. J Med Chem. 2023 Jan 12;66(1):413-434. doi: 10.1021/acs.jmedchem.2c01382. Epub 2022 Dec 26. J Med Chem. 2023. PMID: 36573286 Free PMC article.
• D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity.

  Almansour AI, Kumar RS, Arumugam N, Bianchini G, Menéndez JC, Mohammad F, Dupadahalli K, Altaf M. Almansour AI, et al. Biomed Res Int. 2019 Nov 13;2019:2514524. doi: 10.1155/2019/2514524. eCollection 2019. Biomed Res Int. 2019. PMID: 31815127 Free PMC article.