Promise and pitfalls of the Immunochip

doi:10.1186/ar3204

Review

. 2011 Feb 1;13(1):101.

doi: 10.1186/ar3204.

Promise and pitfalls of the Immunochip

Adrian Cortes¹, Matthew A Brown

Affiliations

PMID: 21345260
PMCID: PMC3157635
DOI: 10.1186/ar3204

Review

Promise and pitfalls of the Immunochip

Adrian Cortes et al. Arthritis Res Ther. 2011.

. 2011 Feb 1;13(1):101.

doi: 10.1186/ar3204.

Authors

Adrian Cortes¹, Matthew A Brown

Affiliation

¹ University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.

PMID: 21345260
PMCID: PMC3157635
DOI: 10.1186/ar3204

Abstract

Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.

PubMed Disclaimer

Cited by

The problems and promises of research into human immunology and autoimmune disease.
Roep BO, Buckner J, Sawcer S, Toes R, Zipp F. Roep BO, et al. Nat Med. 2012 Jan 6;18(1):48-53. doi: 10.1038/nm.2626. Nat Med. 2012. PMID: 22227672 No abstract available.
Introduction.
[No authors listed] [No authors listed] Diabetes Care. 2015 Jan;38 Suppl:S1-2. doi: 10.2337/dc15-S001. Diabetes Care. 2015. PMID: 25537700 No abstract available.
From HLA association to function.
Barrett JC. Barrett JC. Nat Genet. 2012 Feb 27;44(3):235-6. doi: 10.1038/ng.2207. Nat Genet. 2012. PMID: 22366857
Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.
Ortiz-Fernández L, Carmona FD, Montes-Cano MA, García-Lozano JR, Conde-Jaldón M, Ortego-Centeno N, Castillo MJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, Juliá MR, Solans R, Blanco R, Barnosi-Marín AC, Gómez de la Torre R, Fanlo P, Rodríguez-Carballeira M, Rodríguez-Rodríguez L, Camps T, Castañeda S, Alegre-Sancho JJ, Martín J, González-Escribano MF. Ortiz-Fernández L, et al. PLoS One. 2016 Aug 22;11(8):e0161305. doi: 10.1371/journal.pone.0161305. eCollection 2016. PLoS One. 2016. PMID: 27548383 Free PMC article.
Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.
Ye BD, McGovern DP. Ye BD, et al. Expert Rev Clin Immunol. 2016 Oct;12(10):1091-107. doi: 10.1080/1744666X.2016.1184972. Epub 2016 Jun 15. Expert Rev Clin Immunol. 2016. PMID: 27156530 Free PMC article. Review.

See all "Cited by" articles

References

1. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009;461:747–753. doi: 10.1038/nature08494. - DOI - PMC - PubMed
1. Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K. et al.Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464:713–720. doi: 10.1038/nature08979. - DOI - PMC - PubMed
1. Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240–245. doi: 10.1038/ng.286. - DOI - PubMed
1. Slatkin M. Epigenetic inheritance and the missing heritability problem. Genetics. 2009;182:845–850. doi: 10.1534/genetics.109.102798. - DOI - PMC - PubMed
1. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet. 2010;42:565–569. doi: 10.1038/ng.608. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database

[1] Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009;461:747–753. doi: 10.1038/nature08494. - DOI - PMC - PubMed

[2] Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009;461:747–753. doi: 10.1038/nature08494. - DOI - PMC - PubMed

[3] Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K. et al.Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464:713–720. doi: 10.1038/nature08979. - DOI - PMC - PubMed

[4] Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K. et al.Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464:713–720. doi: 10.1038/nature08979. - DOI - PMC - PubMed

[5] Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240–245. doi: 10.1038/ng.286. - DOI - PubMed

[6] Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240–245. doi: 10.1038/ng.286. - DOI - PubMed

[7] Slatkin M. Epigenetic inheritance and the missing heritability problem. Genetics. 2009;182:845–850. doi: 10.1534/genetics.109.102798. - DOI - PMC - PubMed

[8] Slatkin M. Epigenetic inheritance and the missing heritability problem. Genetics. 2009;182:845–850. doi: 10.1534/genetics.109.102798. - DOI - PMC - PubMed

[9] Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet. 2010;42:565–569. doi: 10.1038/ng.608. - DOI - PMC - PubMed

[10] Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet. 2010;42:565–569. doi: 10.1038/ng.608. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Promise and pitfalls of the Immunochip

Affiliation

Promise and pitfalls of the Immunochip

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources