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. 2011 Jan;3(1):14-8.
doi: 10.4103/0974-7796.75862.

Effect of caffeine on bladder function in patients with overactive bladder symptoms

Supatra Lohsiriwat  1 , Muthita Hirunsai, Bansithi Chaiyaprasithi
Affiliations

Effect of caffeine on bladder function in patients with overactive bladder symptoms

Supatra Lohsiriwat et al. Urol Ann. 2011 Jan.

Abstract

Objectives: To evaluate the effect of caffeine at the dose of 4.5 mg/kg on bladder function in overactive bladder (OAB) adults.

Materials and methods: Nine women and three men aged 21-40 years with OAB symptoms were included. Each subject drank 8 ml/kg of water with and without caffeine at two separate sessions. Cystometry and uroflowmetry were performed 30 minutes after each drink. The effects of caffeine on urodynamic parameters were compared.

Results: After caffeine ingestion, the mean volume at bladder filling phase decreased at first desire to void and normal desire to void (P<0.05), compared to the mean volume after taking water (control) drink. The mean volume at strong desire to void, urgency and maximum cystometric capacity also tended to decrease. No change in the detrusor pressure at filling phase was found. At voiding phase, the maximal flow rate, average flow rate and voided volume were increased (P<0.05). The urine flow time and time to maximal flow rate were not changed.

Conclusion: Caffeine at 4.5 mg/kg caused diuresis and decreased the threshold of sensation at filling phase, with an increase in flow rate and voided volume. So, caffeine can promote early urgency and frequency of urination. Individuals with lower urinary tract symptom should avoid or be cautious in consuming caffeine containing foodstuffs.

Keywords: Caffeine; overactive bladder; uroflowmetry.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
Sensation and volumes at bladder filling phases (mean±SE) in milliliters after water and caffeine ingestions (n=12) (FD=first desire to void, ND=normal desire to void, SD=strong desire to void, MCC=maximal cystometric capacity); * P≤0.05 on comparing the volumes after water and caffeine ingestions
Figure 2
Figure 2
Detrusor pressure at filling phase (mean±SE) in mmHg after water and caffeine ingestions (FD=first desire to void, ND=normal desire to void, SD=strong desire to void, MCC=maximal cystometric capacity)
Figure 3
Figure 3
Uroflowmetric parameters (mean±SE) after water and caffeine ingestions (Q 100=flow time, TQmax=time to max flow rate, Qmax =maximal flow rate, QM90=average flow rate, Vcomp=voided volume); *P≤0.05 on comparing the values after water and caffeine ingestions
See this image and copyright information in PMC

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