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. 2008 Mar 1:2008:1-5.

Construction of Multi-dimensional Arterial Health Status Map based on Molecular and Clinical Measurements, Fuzzy System and Data Cubes

Lawrence W C Chan  1 , Iris F F Benzie, Thomas Y H Lau, Yongping Zheng, Alex K S Wong, Y Liu, Phoebe S T Chan
Affiliations

Construction of Multi-dimensional Arterial Health Status Map based on Molecular and Clinical Measurements, Fuzzy System and Data Cubes

Lawrence W C Chan et al. Summit Transl Bioinform. .

Abstract

Atherosclerosis results from inflammatory processes involving biomarkers, such as lipid profile, haemoglobin A1C, oxidative stress, coronary artery calcium score and flow-mediated endothelial response through nitric oxide. This paper proposes a health status coefficient, which comprehends molecular and clinical measurements concerning atherosclerosis to provide a measure of arterial health. An arterial health status map is produced to map the multi-dimensional measurements to the health status coefficient. The mapping is modeled by a fuzzy system embedded with the health domain expert knowledge. The measurements obtained from the pilot study are used to tune the fuzzy system. The inferred arterial health coefficients are stored into the data cubes of a multi-dimensional database. Due to this adaptability and transparency of fuzzy system, the health status map can be easily updated when the refinement of fuzzy rule base is needed or new measurements are obtained.

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Figures

Figure 1.
Figure 1.
ANFIS relates features and %LDR.
Figure 2.
Figure 2.
Arterial Health Status Map
See this image and copyright information in PMC

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References

    1. Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies. Nature Medicine. 2002;8(4):1249–1256. - PubMed
    1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813–820. - PubMed
    1. Choi SW, Benzie IFF, Lam CSY, Chat SWS, Lam J, Yiu CH, Kwan JJ, Tang YH, Yeung GSP, Yeung VTF, Woo GC, Hannigan BM, Strain JJ. Inter-relationships between DNA Damage, Ascorbic Acid and Glycaemic Control in Type 2 Diabetes Mellitus. Diabetic Medicine. 2005;22:1347–1353. - PubMed
    1. Benzie IFF, Strain JJ. The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay. Analytical Biochemistry. 1996;239:70–76. - PubMed
    1. Kullo IJ, Ballantyne CM. Conditional Risk Factors for Atherosclerosis. Mayo Clinic Proceedings. 2005;80(2):219–230. - PubMed

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