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. 2011 Feb 15;6(2):e16818.
doi: 10.1371/journal.pone.0016818.

Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese

Danxia Yu  1 , Zhijie Yu, Qi Sun, Liang Sun, Huaixing Li, Jun Song, Ming Mi, Hongyu Wu, Ling Lu, Chen Liu, Geng Zhang, Frank B Hu, Xu Lin
Affiliations

Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese

Danxia Yu et al. PLoS One. .

Abstract

Background: Little is known regarding the associations between high-molecular-weight (HMW-) adiponectin, leptin and soluble leptin receptor (sOB-R) and metabolic syndrome (MetS) in Chinese. Also few studies elucidate the effects of inflammation and body fat mass on the relations.

Methods: Plasma HMW-adiponectin, leptin and sOB-R were measured among 1055 Chinese men and women (35∼54 yrs). Whole body and trunk fat mass were determined by Dual-energy X-ray absorptiometry. MetS was defined by the updated NCEP/ATPIII criterion for Asian-Americans.

Results: HMW-adiponectin was inversely associated with MetS in multivariate model including fat mass index (FMI), inflammatory markers, leptin and sOB-R (OR in the highest quartile= 0.30, 95%CI 0.18∼0.50, P<.0001). Plasma sOB-R was also inversely associated with MetS independent of body fatness and inflammatory markers, whereas the association was somewhat attenuated after adjusting HMW-adiponectin (OR for the highest quartile = 0.78, 95%CI 0.47∼1.32, P = 0.15). In contrast, leptin was associated with increased odds of MetS independent of inflammatory markers, HMW-adiponectin, and sOB-R (OR for the highest quartile= 2.64, 95%CI 1.35∼5.18, P = 0.006), although further adjustment for FMI abolished this association.

Conclusions: HMW-adiponectin exhibited strong inverse associations with MetS independent of body composition, inflammation, leptin and sOB-R; while the associations of leptin and sOB-R were largely explained by fat mass or HMW-adiponectin, respectively.

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Conflict of interest statement

Competing Interests: Dr. Qi Sun was supported by a postdoctoral fellowship from the Unilever Corporate Research before September 2010. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Figures

Figure 1
Figure 1. Geometric means (95%CI) of concentrations of HMW-adiponectin (A), leptin (B) and soluble leptin receptor (sOB-R, C) in individuals with 0 to 5 components of metabolic syndrome.
Black bars  =  Men; white bars  =  Women. All P values were <.0001.
See this image and copyright information in PMC

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