Envelopment of herpes simplex virus nucleocapsids at the inner nuclear membrane

Excerpt

As in all herpesviruses, Herpes simplex nucleocapsids assembled in the nucleoplasm obtain an initial envelope by budding through the inner nuclear membrane of infected cells. This chapter will focus on the proteins responsible for nucleocapsid budding in the herpes simplex virus system. Of interest is the observation that orthologs of at least the UL31 and UL34 genes of herpes simplex virus genes likely mediate similar functions in members of both the beta- and gamma herpesvirinae (Muranyi et al., ; Gonnella et al., 2005). Thus, it is expected that this information will be relevant to the study of nucleocapsid envelopment of all herpesviruses.