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Review

Envelopment of herpes simplex virus nucleocapsids at the inner nuclear membrane

Joel D. Baines  1
Ann Arvin  1 , Gabriella Campadelli-Fiume  2 , Edward Mocarski  3 , Patrick S. Moore  4 , Bernard Roizman  5 , Richard Whitley  6 , Koichi Yamanishi  7
, editors.
In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 11.
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Review

Envelopment of herpes simplex virus nucleocapsids at the inner nuclear membrane

Joel D. Baines.
Free Books & Documents

Excerpt

As in all herpesviruses, Herpes simplex nucleocapsids assembled in the nucleoplasm obtain an initial envelope by budding through the inner nuclear membrane of infected cells. This chapter will focus on the proteins responsible for nucleocapsid budding in the herpes simplex virus system. Of interest is the observation that orthologs of at least the UL31 and UL34 genes of herpes simplex virus genes likely mediate similar functions in members of both the beta- and gamma herpesvirinae (Muranyi et al., ; Gonnella et al., 2005). Thus, it is expected that this information will be relevant to the study of nucleocapsid envelopment of all herpesviruses.

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References

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    1. Baines J. D., Ward P. L., Campadelli-Fiume G., Roizman B. The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress. J. Virol. 1991;65:6414–6424. - PMC - PubMed
    1. Baines J. D., Jacob R. J., Simmerman L., Roizman B. The UL11 gene products of herpes simplex virus 1 are present in the nuclear and cytoplasmic membranes, and intranuclear dense bodies of infected cells. J. Virol. 1995;69:825–833. - PMC - PubMed
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    1. Bjerke S. L., Cowan J. M., Kerr J. K., Reynolds A. E., Baines J. D., Roller R. J. Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein. J. Virol. 2003;77(13):7601–7610. - PMC - PubMed

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