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Review

Early events in human cytomegalovirus infection

Teresa Compton  1 , Adam Feire  1
Ann Arvin  1 , Gabriella Campadelli-Fiume  2 , Edward Mocarski  3 , Patrick S. Moore  4 , Bernard Roizman  5 , Richard Whitley  6 , Koichi Yamanishi  7
, editors.
In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 16.
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Review

Early events in human cytomegalovirus infection

Teresa Compton et al.
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Excerpt

All viruses must deliver their genomes to host cells to initiate infection. The plasma membrane together with cell surface constituents serve as initial barriers to entry as well as the mediators that facilitate the process. This chapter will summarize what is known about the entry pathway of human cytomegalovirus, noting certain parallels and commonalities between human cytomegalovirus (HCMV) and other betaherpesviruses (see Chapter 46 for specific pathways of HHV-6 and HHV-7 entry). The roles of HCMV envelope glycoproteins and cellular receptors that control virion attachment and membrane fusion will be summarized. This chapter will also discuss the emerging role of signaling pathways in the early events in infection and examine how virus entry and innate immune activation may be coordinated.

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