Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
- PMID: 21348071
- Bookshelf ID: NBK47376
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
Excerpt
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi’s Sarcoma-associated herpesvirus, cytom-egalovirus, HHV6A, 6B, and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Copyright © Cambridge University Press 2007.
Sections
- Contributors
- Preface
- I. Introduction: definition and classification of the human herpesviruses
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II.1. Basic virology and viral gene effects on host cell functions: alphaherpesviruses
- 5. Genetic comparison of human alphaherpesvirus genomes
- 6. Alphaherpes viral genes and their functions
- 7. Entry of alphaherpesviruses into the cell
- 8. Early events pre-initiation of alphaherpes viral gene expression
- 9. Initiation of transcription and RNA synthesis, processing and transport in HSV and VZV infected cells
- 10. Alphaherpesvirus DNA replication
- 11. Envelopment of herpes simplex virus nucleocapsids at the inner nuclear membrane
- 12. The egress of alphaherpesviruses from the cell
- 13. The strategy of herpes simplex virus replication and takeover of the host cell
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II.2. Basic virology and viral gene effects on host cell functions: betaherpesviruses
- 14. Comparative genome and virion structure
- 15. Betaherpes viral genes and their functions
- 16. Early events in human cytomegalovirus infection
- 17. Immediate–early viral gene regulation and function
- 18. Early viral gene expression and function
- 19. DNA synthesis and late viral gene expression
- 20. Maturation and egress
- 21. Viral modulation of the host response to infection
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II.3. Basic virology and viral gene effects on host cell functions: gammaherpesviruses
- 22. Introduction to the human γ-herpesviruses
- 23. Gammaherpesviruses entry and early events during infection
- 24. Maintenance and replication during latency
- 25. Reactivation and lytic replication of EBV
- 26. Reactivation and lytic replication of KSHV
- 27. EBV gene expression and regulation
- 28. KSHV gene expression and regulation
- 29. Effects on apoptosis, cell cycle and transformation, and comparative aspects of EBV with other known DNA tumor viruses
- 30. KSHV manipulation of the cell cycle and apoptosis
- 31. Human gammaherpesvirus immune evasion strategies
- III.1. Pathogenesis, clinical disease, host response, and epidemiology: alphaherpes viruses
- III.2. Pathogenesis, clinical disease, host response, and epidemiology: alphaherpes viruses VZV
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III.3. Pathogenesis, clinical disease, host response, and epidemiology: betaherpesviruses
- 41. Virus entry into host, establishment of infection, spread in host, mechanisms of tissue damage
- 42. Molecular basis of persistence and latency
- 43. Immunobiology and host response
- 44. Persistence in the population: epidemiology and transmisson
- 45. HCMV persistence in the population: potential transplacental transmission
- III.4. HHV-6A, 6B, and 7
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III.5. Pathogenesis, clinical disease, host response, and epidemiology: gammaherpesviruses
- 50. Clinical and pathological aspects of EBV and KSHV infection
- 51. EBV: immunobiology and host response
- 52. Immunobiology and host response to KSHV infection
- 53. The epidemiology of EBV and its association with malignant disease
- 54. The epidemiology of KSHV and its association with malignant disease
- 55. EBV-induced oncogenesis
- 56. KSHV-induced oncogenesis
- IV. Non-human primate herpesviruses
- V. Subversion of adaptive immunity
- VI. Antiviral therapy
- VII. Vaccines and immunotherapy
- VIII. Herpesviruses as therapeutic agents
- Plates
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