Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Comparative genome and virion structure

Andrew J. Davison  1 , David Bhella  1
Ann Arvin  1 , Gabriella Campadelli-Fiume  2 , Edward Mocarski  3 , Patrick S. Moore  4 , Bernard Roizman  5 , Richard Whitley  6 , Koichi Yamanishi  7
, editors.
In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 14.
Affiliations
Free Books & Documents
Review

Comparative genome and virion structure

Andrew J. Davison et al.
Free Books & Documents

Excerpt

The two major lineages in the Betaherpesvirinae are the cytomegaloviruses (the Cytomegalovirus and Muromegalovirus genera, plus a number of other viruses whose taxonomy is only partially defined) and the Roseolovirus genus (see Chapter 1). The best characterized members of these lineages are HCMV (the prototype of the subfamily) and HHV-6, respectively. Cytomegaloviruses are present in a wide range of mammalian species, and have been termed “salivary gland viruses” because of their ease of isolation from explanted tissue. An earlier divergence of the Betaherpesvirinae may be represented by a herpesvirus of elephants (Richman et al., ; Ehlers et al., 2001). This chapter starts by describing the genome structures of Betaherpesvirinae, then examines the genetic content of HCMV and HHV-6, and finally focuses on the virion structure of HCMV.

PubMed Disclaimer

References

    1. Adair R., Douglas E. R., Maclean J. B., et al. The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are tegument components. J. Gen. Virol. 2002;83:1315–1324. - PubMed
    1. Adamo J. E., Schroer J., Shenk T. Human cytomegalovirus TRS1 protein is required for efficient assembly of DNA-containing capsids. J. Virol. 2004;78:10221–10229. - PMC - PubMed
    1. Adler B., Scrivano L., Ruzcics Z., Rupp B., Sinzger C., Koszinowski U. Role of human cytomegalovirus UL131A in cell type-specific virus entry and release. J. Gen. Virol. 2006;87:2451–2460. - PubMed
    1. Agulnick A. D., Thompson J. R., Iyengar S., Pearson G., Ablashi D., Ricciardi R. P. Identification of a DNA-binding protein of human herpesvirus 6, a putative DNA polymerase stimulatory factor. J. Gen. Virol. 1993;74:1003–1009. - PubMed
    1. Ahn J. H., Hayward G. S. Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection. Virology. 2000;274:39–55. - PubMed

LinkOut - more resources