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Review

Genetic comparison of human alphaherpesvirus genomes

Joel D. Baines  1 , Philip E. Pellett  2
Ann Arvin  1 , Gabriella Campadelli-Fiume  2 , Edward Mocarski  3 , Patrick S. Moore  4 , Bernard Roizman  5 , Richard Whitley  6 , Koichi Yamanishi  7
, editors.
In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 5.
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Review

Genetic comparison of human alphaherpesvirus genomes

Joel D. Baines et al.
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Excerpt

Human herpesviruses 1, 2, and 3 (herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2), and varicella-zoster virus (VZV)) have been classified as alphaherpesviruses based originally upon their biological properties, and subsequently on the sequences of their respective genomes (Minson et al., ; Pellett and Roizman, in press). All of these viruses maintain latent infections in sensory ganglia, and can productively infect a variety of human cells, including the living cells of mucous membranes and skin. These epithelial sites also provide exit points for the virus to infect other individuals.

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References

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