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Review

Introduction to the human γ-herpesviruses

Richard Longnecker  1 , Frank Neipel  2
Ann Arvin  1 , Gabriella Campadelli-Fiume  2 , Edward Mocarski  3 , Patrick S. Moore  4 , Bernard Roizman  5 , Richard Whitley  6 , Koichi Yamanishi  7
, editors.
In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 22.
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Review

Introduction to the human γ-herpesviruses

Richard Longnecker et al.
Free Books & Documents

Excerpt

This chapter will provide a brief background into the γ-herpesviruses family in comparison to other members of the herpesvirus family; but the primary focus of this chapter will be to recount the discovery of the two human γ-herpesviruses (EBV and KSHV) and the diseases associated with infection of each virus, a brief introduction into their life cycles, and finally a description of the genome characteristics of the viruses including a description of their respective genomes. In many ways, the discovery and association with human diseases for both EBV and KSHV have many parallels despite almost three decades separating their discoveries and association with human disease.

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References

General historical reading

    1. Coakley, D. (1992Irish masters of medicine Town House Publishing, 333–344.
    1. Epstein A. Thirty years of Epstein–Barr virus. Epstein–Barr Virus Report. 1994;1(1):3–4.
    1. Epstein A. On the discovery of Esptein–Barr virus: a memoir. Epstein–Barr Virus Report. 1999;6(3):58–63.
    1. Glermser, B. (1970). Mr. Burkitt and Africa New York and Cleveland: The World Publishing Company
    1. Henle W., Henle G., Lennette E. T. The Epstein–Barr virus. Sci. Am. 1979;241(1):48–59. - PubMed

References

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    1. Andreoni M., Sarmati L., Nicastri E., et al. Primary human herpesvirus 8 infection in immunocompetent children. 2002;287(10):1295–1300. - PubMed
    1. Arvanitakis L., Mesri E. A., Nador R. G., et al. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein–Barr virus. Blood. 1996;88(7):2648–2654. - PubMed
    1. Babcock G. J., Lawson D. A. and Thorley-2000Tonsillar memory B cells, latently infected with Epstein–Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors Proc. Natl Acad. Sci. USA 972212250–12255. - PMC - PubMed
    1. Babcock G. J., Decker L. L., Volk M., Lawson D. A., and Thorley-1998EBV persistence in memory B cells in vivo Immunity 93395–404. - PubMed

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