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. 2011 May;32(5):898-902.
doi: 10.3174/ajnr.A2395. Epub 2011 Feb 24.

Apparent diffusion coefficients of metabolites in patients with MELAS using diffusion-weighted MR spectroscopy

Z Liu  1 , D Zheng, X Wang, J Zhang, S Xie, J Xiao, X Jiang
Affiliations

Apparent diffusion coefficients of metabolites in patients with MELAS using diffusion-weighted MR spectroscopy

Z Liu et al. AJNR Am J Neuroradiol. 2011 May.

Abstract

Background and purpose: DW-MR spectroscopy can detect the diffusion coefficients of NAA, Cr, PCr, and Cho and can, therefore, provide some useful information. The aims of this study were to probe the mechanisms underlying the pathogenesis of MELAS and to see whether DW-MR spectroscopy is a useful technique for other diseases besides cerebral infarction.

Materials and methods: Fifteen healthy volunteers and 10 patients with MELAS were enrolled in the study. All were scanned on a 3T whole-body MR imaging scanner. Fifteen ADCs of the singlet metabolites in the gray matter of the healthy subjects, 10 ADCs of the singlet metabolites in the lesions, and 8 ADCs of the singlet metabolites in the nonaffected areas were used in the statistical analysis, respectively.

Results: The metabolite ADCs of the nonaffected areas and the lesions in the patients were higher than those of the frontal gray matter in the healthy controls. There were significant differences between the metabolite ADCs of the nonaffected areas in patients and those in the healthy controls, and it was the same with the metabolite ADCs of the lesions and those of the healthy controls.

Conclusions: The increased ADC values of the metabolites reveal that MELAS is a mitochondrial neuronopathy and involves the entire brain. DW-MR spectroscopy is a very useful noninvasive technique, which can show some valuable information that conventional MR imaging cannot display. Thus, it can be applied to brain diseases besides cerebral infarction.

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Figures

Fig 1.
Fig 1.
A, A VOI is seen in the gray matter of the frontal lobe in a healthy subject. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).
Fig 2.
Fig 2.
A, A VOI is seen in the nonaffected frontal lobe in a patient with MELAS. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).
Fig 3.
Fig 3.
A, A VOI is seen in the previously affected area of the patient with MELAS. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).
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