Too much ara-C? Not enough daunorubicin?

Eric J Feldman¹

Affiliations

PMID: 21350058
DOI: 10.1182/blood-2011-01-328633

Free article

Comment

Too much ara-C? Not enough daunorubicin?

Eric J Feldman. Blood. 2011.

Free article

. 2011 Feb 24;117(8):2299-300.

doi: 10.1182/blood-2011-01-328633.

Author

Eric J Feldman¹

Affiliation

¹ Weill-Cornell Medical College.

PMID: 21350058
DOI: 10.1182/blood-2011-01-328633

Abstract

It seems strange, but after 40 years of experience using cytosine arabinoside (ara-C) and daunorubicin, leukemia doctors are still unsure as to how much of each drug they should use to treat their patients with acute myeloid leukemia (AML).

PubMed Disclaimer

Comment on

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R. Ohtake S, et al. Blood. 2011 Feb 24;117(8):2358-65. doi: 10.1182/blood-2010-03-273243. Epub 2010 Aug 6. Blood. 2011. PMID: 20693429 Clinical Trial.
A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study.
Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R. Miyawaki S, et al. Blood. 2011 Feb 24;117(8):2366-72. doi: 10.1182/blood-2010-07-295279. Epub 2010 Dec 29. Blood. 2011. PMID: 21190996 Clinical Trial.

Publication types

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Silverchair Information Systems
Other Literature Sources
- The Lens - Patent Citations Database

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Too much ara-C? Not enough daunorubicin?

Affiliation

Too much ara-C? Not enough daunorubicin?

Author

Affiliation

Abstract

Comment on

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources