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Comment
. 2011 Mar;43(3):178-9.
doi: 10.1038/ng0311-178.

A twist on admixture mapping

Stephen J Chanock
Comment

A twist on admixture mapping

Stephen J Chanock. Nat Genet. 2011 Mar.

Abstract

A new study uses genome-wide SNP genotypes to identify a subset of children undergoing therapy for acute lymphoblastic leukemia that are at increased risk for relapse. Borrowing from the classical approach of admixture mapping, the work shows how genome-wide assessment of genetic ancestry can be used as a biomarker for disease outcome.

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Comment on

  • Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.
    Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui CH, Evans WE, Relling MV. Yang JJ, et al. Nat Genet. 2011 Mar;43(3):237-41. doi: 10.1038/ng.763. Epub 2011 Feb 6. Nat Genet. 2011. PMID: 21297632 Free PMC article.

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