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Comment
. 2011 Mar;43(3):180-1.
doi: 10.1038/ng0311-180.

The long and winding road from correlation to causation

Michel Georges
Comment

The long and winding road from correlation to causation

Michel Georges. Nat Genet. 2011 Mar.

Abstract

Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.

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References

    1. Nat Cell Biol. 2010 Dec;12(12):1154-65 - PubMed
    1. PLoS Genet. 2009 Mar;5(3):e1000403 - PubMed
    1. Nat Genet. 2011 Mar;43(3):242-5 - PubMed
    1. RNA. 2010 Sep;16(9):1854-63 - PubMed
    1. Nat Genet. 2007 May;39(5):596-604 - PubMed

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