[Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity]
[Article in
Chinese]
Affiliations
- PMID: 21351438
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[Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity]
[Article in
Chinese]
Yao Xue Xue Bao.
2010 Feb.
Abstract
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).