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Comparative Study
. 2011 Feb 27:6:20.
doi: 10.1186/1749-8090-6-20.

Effect of Ankaferd Blood Stopper on air leakage in the lung and prevention of bleeding: an experimental study

Ali Kılıçgün  1 , Necla G Sarıkaş, Tanzer Korkmaz, Ozkan Saydam, Cetin Boran, Güledal Boztaş
Affiliations
Comparative Study

Effect of Ankaferd Blood Stopper on air leakage in the lung and prevention of bleeding: an experimental study

Ali Kılıçgün et al. J Cardiothorac Surg. .

Abstract

Background: Air leakage and hemorrhage are important causes of morbidity and mortality in operations and traumas of the lung. Ankaferd Blood Stopper is a herbal product used for stopping hemorrhage. In our study, we investigated the efficacy of Ankaferd Blood Stopper in the prevention of air leakage in the lung and bleeding.

Methods: A total of twenty-one Wistar-Albino rats weighing 240 ± 20 grams were used in our study. An equal amount of injury was created in all groups by performing left thoracotomies. No interventions were made on tissue injury in the first group, and suturing was performed in the second group, and Ankaferd was applied in the third group. Air leakage and duration of bleeding were recorded in all groups.

Results: A statistically significant difference was found between the three groups in terms of air leakage time (p = 0,0001) and bleeding time (p = 0,0001). While a significant effect of Ankaferd was detected in terms of air leakage compared to standard surgery (p = 0,017), no difference was found in terms of bleeding time.

Conclusions: Ankaferd Blood Stopper ceases the air leakage in the lung parenchyma significantly and effectively. No significant difference is seen compared to the standard surgery group, although it ceases bleeding significantly.

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Figures

Figure 1
Figure 1
Distribution of air leakage and bleeding times in the control group (Group 1, n = 7), standard surgery group (Group 2, n = 7) and Ankaferd Blood Stopper group (Group 3, n = 7).
Figure 2
Figure 2
Appearance of lung tissue of the normal rats ( H&E, X200).
Figure 3
Figure 3
Changes in the early period (intraoperative) in the lung in which Ankaferd was applied. Hemolyzed clot masses (blood-fibrin masses) are observed in the areas exposed to Ankaferd ( H&E, X200)
Figure 4
Figure 4
Histopathological changes on the 5. day in the lung in which Ankaferd was applied. Newly organized fibrin plugs are observed in the alveoli of the lung of Ankaferd-applied rats( H&E, X200)
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