doi: 10.3109/09687689009025843.
Differences in the plasma membrane proteins of chronic alcoholic rat brain
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- PMID: 2135304
- DOI: 10.3109/09687689009025843
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Differences in the plasma membrane proteins of chronic alcoholic rat brain
Membr Biochem.
1990 Jul-Sep.
Abstract
Plasma membranes were isolated from the cerebral cortex of control and chronic ethanol-treated rat brains. Analysis of protein composition by SDS-PAGE and by two-dimensional gel electrophoresis (IEF-SDS-PAGE) revealed significant differences in the membrane protein patterns between control and ethanol-treated rat cerebral cortices, indicating the loss of several proteins in membranes from ethanol-treated rat brains. Plasma membrane-associated protein species are categorized into ethanol-sensitive and -insensitive proteins, based on their response to ethanol. This study reports that ethanol depletes certain intrinsic proteins of membranes that might be responsible for plasma membrane disruption by ethanol.
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