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Comment
. 2011 Mar 2;13(3):236-8.
doi: 10.1016/j.cmet.2011.02.008.

Endothelium-dependent delivery of insulin to muscle interstitium

Christian Rask-Madsen  1 , George L King
Affiliations
Comment

Endothelium-dependent delivery of insulin to muscle interstitium

Christian Rask-Madsen et al. Cell Metab. .

Abstract

Insulin contributes to skeletal muscle glucose uptake by increasing blood flow and recruiting perfused capillaries. In this issue of Cell Metabolism, Kubota et al. (2011) show that deletion of IRS-2 in endothelial cells in mice causes impaired transcapillary insulin transport, decreased insulin-stimulated glucose uptake in muscle, and mild glucose intolerance.

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Comment on

  • Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
    Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T. Kubota T, et al. Cell Metab. 2011 Mar 2;13(3):294-307. doi: 10.1016/j.cmet.2011.01.018. Cell Metab. 2011. PMID: 21356519

References

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