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Editorial
. 2011 Mar;89(3):327-8.
doi: 10.1189/jlb.1010580.

Editorial: One small molecule: a new way to treat the flu?

Editorial

Editorial: One small molecule: a new way to treat the flu?

Howard Young. J Leukoc Biol. 2011 Mar.

Abstract

DMXAA, a small molecule undergoing clinical trials for solid tumors, is now shown to have in vivo anti-viral activity.

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References

    1. Shirey K. A., Nhu Q. M., Yim K. C., Roberts Z. J., Teijaro J. R., Farber D. L., Blanco J. C., Vogel S. N. (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J. Leukoc. Biol. 89, 351–357 - PMC - PubMed
    1. Perera P. Y., Barber S. A., Ching L. M., Vogel S. N. (1994) Activation of LPS-inducible genes by the antitumor agent 5,6-dimethyl-xanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J. Immunol. 153, 4684–4693 - PubMed
    1. Roberts Z. J., Goutagny N., Perera P. Y., Kato H., Kumar H., Kawai T., Akira S., Savan R., van Echo D., Fitzgerald K. A., Young H. A., Ching L. M., Vogel S. N. (2007) The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J. Exp. Med. 204, 1559–1569 - PMC - PubMed
    1. Hornung R. L., Young H. A., Urba W. J., Wiltrout R. H. (1988) Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon α/β. J. Natl. Cancer Inst. 80, 1226–1231 - PubMed
    1. Corbett T. H., Bissery M. C., Wozniak A., Plowman J., Polin L., Tapazoglou E., Dieckman J., Valeriote F. (1986) Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Invest. New Drugs 4, 207–220 - PubMed

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