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Comment

. 2011 Mar;60(3):697-9.

doi: 10.2337/db10-1782.

Cytokines and type 1 diabetes: a numbers game

Lars Groth Grunnet¹, Thomas Mandrup-Poulsen

Affiliations

PMID: 21357470
PMCID: PMC3046829
DOI: 10.2337/db10-1782

Comment

Cytokines and type 1 diabetes: a numbers game

Lars Groth Grunnet et al. Diabetes. 2011 Mar.

. 2011 Mar;60(3):697-9.

doi: 10.2337/db10-1782.

Authors

Lars Groth Grunnet¹, Thomas Mandrup-Poulsen

Affiliation

¹ Core Unit for Medical Research Methodology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 21357470
PMCID: PMC3046829
DOI: 10.2337/db10-1782

No abstract available

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Figures

FIG. 1. — FIG. 1.
Effects of anti–IL-21 treatment on type 1 diabetes progression and graft destruction. New knowledge provided by McGuire et al. (8) is highlighted in gray boxes. T1D, type 1 diabetes.

See this image and copyright information in PMC

Comment on

Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
McGuire HM, Walters S, Vogelzang A, Lee CM, Webster KE, Sprent J, Christ D, Grey S, King C. McGuire HM, et al. Diabetes. 2011 Mar;60(3):867-75. doi: 10.2337/db10-1157. Diabetes. 2011. PMID: 21357471 Free PMC article.

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References

1. Mathis D, Vence L, Benoist C. β-Cell death during progression to diabetes. Nature 2001;414:792–798 - PubMed
1. Rabinovitch A, Suarez-Pinzon WL. Role of cytokines in the pathogenesis of autoimmune diabetes mellitus. Rev Endocr Metab Disord 2003;4:291–299 - PubMed
1. Eizirik DL, Mandrup-Poulsen T. A choice of death—the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001;44:2115–2133 - PubMed
1. Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57–63 - PubMed
1. Spolski R, Kashyap M, Robinson C, Yu Z, Leonard WJ. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci USA 2008;105:14028–14033 - PMC - PubMed

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