Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2011 Apr;34(4):994-9.
doi: 10.2337/dc10-1593. Epub 2011 Feb 28.

Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status

Tanja C Adam  1 , Rebecca E Hasson, Christianne J Lane, Jaimie N Davis, Marc J Weigensberg, Donna Spruijt-Metz, Michael I Goran
Affiliations
Clinical Trial

Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status

Tanja C Adam et al. Diabetes Care. 2011 Apr.

Abstract

Objective: To examine the relationship of fasting indicators of insulin sensitivity with a more invasive measure of insulin sensitivity (frequently sampled intravenous glucose tolerance test [FSIVGTT]) and the effect of Tanner stage and ethnicity on that relationship.

Research design and methods: Data were analyzed from 149 overweight girls (97 Hispanic and 52 African American) who were either in the early stages of maturation defined by Tanner stages 1 or 2 (52 Hispanic and 18 African American) or in the later stages of maturation defined by Tanner stages 4 and 5 (45 Hispanic and 34 African American). Fasting indicators of insulin sensitivity (IS) included fasting insulin and glucose and the homeostasis model assessment of insulin resistance (HOMA-IR). IS was derived from an FSIVGTT with minimal modeling.

Results: In Tanner stages 1 and 2, all fasting indicators were significantly associated with IS: (fasting insulin: r = -0.67, P < 0.01; HOMA: r = -0.66, P < 0.01) with no significant influence of ethnicity on these relationships. In Tanner stages 4 and 5, however, all fasting indicators were associated with IS in African American girls (fasting insulin: r = -0.55, P < 0.01; HOMA: r = -0.47, P < 0.01), but none of the indicators were significantly associated with IS in Hispanic girls.

Conclusions: Fasting indicators were reflective of IS for girls in Tanner stages 1 and 2, regardless of ethnicity and may provide a clinical measure of future risk for type 2 diabetes. In the latter stages of maturation, however, more invasive measures are warranted to adequately determine IS in clinical practice.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Relationship of fasting insulin (A) and HOMA (B) with IS in Tanner stages 1 and 2.
Figure 2
Figure 2
Relationship of fasting insulin (A) and HOMA (B) with IS in Tanner stages 4 and 5.
See this image and copyright information in PMC

References

    1. Goran MI, Lane C, Toledo-Corral C, Weigensberg MJ. Persistence of pre-diabetes in overweight and obese Hispanic children: association with progressive insulin resistance, poor beta-cell function, and increasing visceral fat. Diabetes 2008;57:3007–3012 - PMC - PubMed
    1. Dabelea D, Bell RA, D’Agostino RB, Jr, et al. Writing Group for the SEARCH for Diabetes in Youth Study Group Incidence of diabetes in youth in the United States. JAMA 2007;297:2716–2724 - PubMed
    1. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK. Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1986;315:220–224 - PubMed
    1. Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics 2001;108:712–718 - PubMed
    1. Goran MI, Bergman RN, Cruz ML, Watanabe R. Insulin resistance and associated compensatory responses in African-American and Hispanic children. Diabetes Care 2002;25:2184–2190 - PubMed

Publication types