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Review
. 2011 Feb;26(1):45-53.
doi: 10.1152/physiol.00040.2010.

Spontaneous neurotransmission: an independent pathway for neuronal signaling?

Ege T Kavalali  1 , Chihye Chung, Mikhail Khvotchev, Jeremy Leitz, Elena Nosyreva, Jesica Raingo, Denise M O Ramirez
Affiliations
Free article
Review

Spontaneous neurotransmission: an independent pathway for neuronal signaling?

Ege T Kavalali et al. Physiology (Bethesda). 2011 Feb.
Free article

Abstract

Recent findings suggest that spontaneous neurotransmission is a bona fide pathway for interneuronal signaling that operates independent of evoked transmission via distinct presynaptic as well as postsynaptic substrates. This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation.

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